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PROfusion Discovery EngineHow do we use PROfusion™? We generate Adnectins™ from human fibronectins by applying our proprietary protein engineering system, PROfusion. It capitalizes on the inherent advantages of the Adnectin class through the rapid and efficient engineering, evaluation and optimization of Adnectin product candidates. Our scientists use our proprietary PROfusion system to simultaneously engineer trillions of Adnectin protein variations at a time in order to find the optimal product candidate. This has the potential of increasing pipeline productivity by reducing the time and cost of identifying high quality product candidates. How does PROfusion work? The power of PROfusion is based on its ability to go from DNA to RNA to protein without using cells, while also directly attaching a unique tag to each protein variant. These tags help our scientists track Adnectins with the most desirable properties for product candidates. The tag that PROfusion attaches is the unique mRNA that was used to synthesize that specific protein variant. Through PROfusion, we can efficiently identify Adnectins with a constellation of desired therapeutic properties, such as high target affinity and specificity, favorable formulation properties, and high yield manufacturing. Our ability to use PROfusion in this way greatly accelerates Adnectin drug discovery and development. We believe PROfusion provides us with significant competitive advantages, including the ability to:
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